Parent Product
Vitamin B9 (Folic Acid)
Last Updated
2026-06-17
Key takeaways for search and sourcing teams
- Calcium L-methylfolate market coverage spans 20 countries.
- 115 exporter companies and 164 importer companies are indexed in the global supply chain intelligence network for this product.
- 90 supplier-linked transactions are summarized across the top 11 countries.
- 0 premium suppliers and 0 catalog items are currently listed.
- Wholesale sample entries: 0; farmgate sample entries: 0.
- Page data last updated on 2026-06-17.
Global Supplier Transactions, Export Activity, and Price Benchmarks for Calcium L-methylfolate
Analyze 90 supplier-linked transactions across the top 11 countries, with monthly unit-price benchmarks to track export competitiveness and sourcing risk for Calcium L-methylfolate.
Calcium L-methylfolate Country YoY Change in Supplier Transactions and Export Momentum
Compare positive and negative YoY shifts in Calcium L-methylfolate to identify accelerating supplier markets and weakening export corridors.
Top YoY shifts for Calcium L-methylfolate: Italy (+13366.2%), China (+161.9%), Switzerland (+82.2%).
Calcium L-methylfolate Country-Level Supplier Transaction and Unit Price Summary
As of 2025-07, benchmark Calcium L-methylfolate country transaction counts with monthly unit price and volume to prioritize supplier and export markets.
In 2025-12, countries with visible Calcium L-methylfolate transaction unit prices: United States (253.33 USD / kg), France (44.07 USD / kg), Spain (42.25 USD / kg), Italy (42.03 USD / kg), China (31.35 USD / kg), 1 more countries.
| Country | YoY Change | Transaction Count | 2025-07 | 2025-08 | 2025-09 | 2025-10 | 2025-11 | 2025-12 | 2026-01 | 2026-02 | 2026-03 | 2026-04 | 2026-05 | 2026-06 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Italy | +13366.2% | 9 | 39.34 USD / kg (727 kg) | - (-) | - (-) | 40.84 USD / kg (90.5 kg) | - (-) | 42.03 USD / kg (7,280 kg) | ||||||
| Pakistan | +15.4% | 1 | - (-) | - (-) | - (-) | - (-) | - (-) | - (-) | ||||||
| France | +69.8% | 16 | - (-) | 42.52 USD / kg (1,727 kg) | 29.97 USD / kg (476 kg) | 43.84 USD / kg (671 kg) | 36.33 USD / kg (1,906 kg) | 44.07 USD / kg (480.48 kg) | ||||||
| United States | +11.6% | 21 | 174.41 USD / kg (79.82 kg) | - (-) | 145.47 USD / kg (453.59 kg) | 187.06 USD / kg (39.44 kg) | 183.73 USD / kg (11.8 kg) | 253.33 USD / kg (8.4 kg) | ||||||
| China | +161.9% | 18 | - (-) | 24.80 USD / kg (2,000 kg) | 33.06 USD / kg (601 kg) | 374.65 USD / kg (50 kg) | - (-) | 31.35 USD / kg (5,400 kg) | ||||||
| Spain | -35.0% | 10 | 73.42 USD / kg (8,893 kg) | - (-) | - (-) | 45.34 USD / kg (23,690 kg) | - (-) | 42.25 USD / kg (384 kg) | ||||||
| Turkiye | -31.6% | 2 | - (-) | - (-) | 17.88 USD / kg (104 kg) | - (-) | - (-) | 14.99 USD / kg (432 kg) | ||||||
| United Arab Emirates | - | 7 | - (-) | - (-) | 186.12 USD / kg (1 kg) | - (-) | 61.95 USD / kg (1 kg) | - (-) | ||||||
| Russia | -33.5% | 3 | 33.27 USD / kg (10.37 kg) | - (-) | 36.14 USD / kg (21.88 kg) | - (-) | - (-) | - (-) | ||||||
| India | -43.3% | 2 | 352.02 USD / kg (5 kg) | - (-) | - (-) | - (-) | - (-) | - (-) |
Calcium L-methylfolate Global Supply Chain Coverage
279 companies
115 exporters and 164 importers are mapped for Calcium L-methylfolate.
Exporters and importers can use Tridge Supply Chain Intelligence company profiles and analytics to identify counterparties for Calcium L-methylfolate, benchmark reach, and prioritize outreach by market.
Calcium L-methylfolate Export Supplier Intelligence, Trade Flows, and Price Signals
115 exporter companies are mapped in Tridge Supply Chain Intelligence for Calcium L-methylfolate. Exporters and importers can use company profiles and analytics to evaluate supplier coverage, trading activity, and route opportunities.
Calcium L-methylfolate Top Exporters and Supplier Profiles
Review leading exporter profiles while benchmarking against 115 total exporter companies in the Calcium L-methylfolate supply chain intelligence network. Exporters and importers can unlock company profiles and analytics to qualify partners faster.
(China)
Latest Export Transaction: 2026-05-17
Industries: Fishing AquacultureFood ManufacturingOthers
Value Chain Roles: Farming / Production / Processing / PackingTrade
Exporting Countries: Argentina
Supplying Products: Vitamin Raw Material, Single Vitamin Material, Vitamin B9 (Folic Acid) +1
(Belgium)
Latest Export Transaction: 2026-05-17
Employee Size: 11 - 50 Employees
Industries: Food ManufacturingOthers
Value Chain Roles: Food ManufacturingTrade
Exporting Countries: Vietnam
Supplying Products: Vitamin Raw Material, Single Vitamin Material, Vitamin B9 (Folic Acid) +1
(Germany)
Latest Export Transaction: 2026-05-17
Employee Size: 51 - 100 Employees
Sales Revenue: USD 10M - 50M
Industries: Others
Value Chain Roles: Distribution / Wholesale
Exporting Countries: Russia
Supplying Products: Vitamin Raw Material, Single Vitamin Material, Vitamin B9 (Folic Acid) +1
(Canada)
Latest Export Transaction: 2026-05-17
Industries: Beverage ManufacturingFood ManufacturingFood Packaging
Value Chain Roles: Distribution / WholesaleFood Manufacturing
Exporting Countries: Vietnam
Supplying Products: Vitamin Raw Material, Single Vitamin Material, Vitamin B9 (Folic Acid) +1
(India)
Latest Export Transaction: 2026-05-17
Industries: Others
Value Chain Roles: Trade
Exporting Countries: Mexico, Germany, Thailand, Italy, Spain, Colombia, Canada, South Africa, Netherlands, Portugal
Supplying Products: Vitamin Raw Material, Single Vitamin Material, Vitamin B9 (Folic Acid) +1
(India)
Latest Export Transaction: 2026-05-17
Employee Size: 101 - 500 Employees
Sales Revenue: USD 1M - 5M
Industries: Food ManufacturingFood Services And Drinking Places
Value Chain Roles: Farming / Production / Processing / PackingFood Manufacturing
Exporting Countries: Tanzania
Supplying Products: Vitamin Raw Material, Immunity Shot, Curcumin +3
Calcium L-methylfolate Global Exporter Coverage
115 companies
Exporter company count is a key signal for Calcium L-methylfolate supply depth and sourcing optionality.
Use Supply Chain Intelligence analytics to narrow Calcium L-methylfolate opportunities by country, product, and value-chain role, then open company profiles to validate fit.
Calcium L-methylfolate Import Buyer Intelligence, Demand Signals, and Price Benchmarks
164 importer companies are mapped for Calcium L-methylfolate demand intelligence. Use Supply Chain Intelligence company profiles and analytics to prioritize buyers, distributors, and downstream demand partners by market.
Calcium L-methylfolate Top Buyers, Importers, and Demand Partners
Review leading buyer profiles and compare them against 164 total importer companies tracked for Calcium L-methylfolate. Exporters and importers can use Supply Chain Intelligence company profiles and analytics to evaluate buyer quality and demand concentration.
(Jordan)
Latest Import Transaction: 2026-05-17
Industries: Food Wholesalers
Value Chain Roles: -
(Colombia)
Latest Import Transaction: 2026-05-17
Employee Size: 11 - 50 Employees
Industries: Others
Value Chain Roles: -
(Vietnam)
Latest Import Transaction: 2026-05-17
Industries: Beverage ManufacturingFood ManufacturingOthers
Value Chain Roles: -
(Colombia)
Latest Import Transaction: 2026-05-17
Employee Size: 11 - 50 Employees
Sales Revenue: USD 1M - 5M
Industries: Others
Value Chain Roles: -
(Mexico)
Latest Import Transaction: 2025-11-22
Employee Size: 101 - 500 Employees
Sales Revenue: USD 50M - 100M
Industries: Others
Value Chain Roles: -
(Tanzania)
Latest Import Transaction: 2026-05-17
Industries: Others
Value Chain Roles: -
Global Importer Coverage
164 companies
Importer company count highlights the current depth of demand-side visibility for Calcium L-methylfolate.
Use Supply Chain Intelligence analytics and company profiles to identify active Calcium L-methylfolate buyers, compare partner density by country, and refine GTM priorities.
Classification
Product TypeIngredient
Product FormPowder
Industry PositionDietary Supplement Ingredient
Market
Calcium L-methylfolate (levomefolate calcium; L-5-MTHF-Ca) is a synthetic, bioactive folate (vitamin B9) ingredient used in dietary supplements and, in some jurisdictions, as a nutrient source for certain fortified/regulated nutrition uses. EFSA has assessed calcium L-methylfolate and related 5-MTHF salts for bioavailability and for conversion into dietary folate equivalents (DFE), anchoring how this ingredient is treated in EU nutrition contexts. Commercial supply is largely B2B, sold as quality-system materials (e.g., USP-referenced offerings) where identity (e.g., the (6S) form) and documentation (COA/COQ) are central to procurement. Handling and storage conditions can be material to buyer acceptance, with some commercial products specifying refrigerated storage (e.g., 2–8°C).
Specification
Major Varieties(6S)-5-methyltetrahydrofolic acid, calcium salt (L-5-MTHF-Ca; levomefolate calcium)
Physical Attributes
- Synthetic powder form (supplier-described)
- Marketed as a stable crystalline form of L-methylfolate calcium (supplier-described)
Compositional Metrics
- Defined as the (6S) stereoisomer of 5-methyltetrahydrofolic acid in calcium salt form
- Included in EFSA evaluations of 5-MTHF sources used for DFE conversion in EU nutrition contexts
Grades
- USP (as referenced by some commercial offerings)
- GMP-aligned food/pharma grade (supplier-declared; commonly paired with documented COA/COQ)
Packaging
- Bulk B2B packaging accompanied by supplier documentation (e.g., COA/COQ); customized packaging is offered by some suppliers
ProcessingCalcium salt is described as sparingly soluble compared with some alternative 5-MTHF salts, which can influence formulation choices
Supply Chain
Value Chain
- Synthetic manufacture and purification → stabilized crystalline calcium salt → quality release documentation (COA/COQ) → bulk distribution to premix/supplement manufacturers → downstream blending and dosage-form manufacturing (capsules/tablets) → retail and regulated nutrition channels
Demand Drivers
- Use of 5-MTHF (L-methylfolate) as a dietary supplement folate form
- Jurisdictional regulatory recognition and labeling frameworks for 5-MTHF salts (e.g., EFSA scientific opinions and DFE conversion approaches)
- Buyer preference for documented identity and quality systems (e.g., USP-referenced, GMP/halal/kosher supplier grades)
Temperature
- Some commercial calcium L-methylfolate products specify refrigerated storage (e.g., 2–8°C), making temperature control a practical procurement and logistics consideration
Risks
Quality And Stability HighCalcium L-methylfolate is a reduced folate ingredient sold against tight identity/potency and documentation expectations; inadequate storage and handling can increase the risk of out-of-spec material and downstream batch rejection or recall. Some commercial offerings explicitly specify refrigerated storage (e.g., 2–8°C), which tightens cold-chain discipline requirements for global trade.Specify storage and transport conditions in contracts; use validated packaging and lane qualification; verify potency/identity on receipt and through shelf life using agreed methods and COA alignment.
Regulatory Compliance MediumNutrition-policy and labeling treatment of 5-MTHF sources can be jurisdiction-specific, including how calcium L-methylfolate is converted into dietary folate equivalents (DFE) and how upper intake considerations are framed for folate forms (including 5-MTHF salts). Misalignment can create relabeling, reformulation, or market-access delays.Maintain a destination-market regulatory matrix for permitted folate sources and labeling; keep dossiers updated; validate claims and DFE calculations against current authoritative guidance.
Market Access And Specification Tightness MediumProcurement frequently relies on high-documentation, high-purity specifications (e.g., defined (6S) identity and pharmacopeial/quality-system positioning). Switching between branded and non-branded sources can trigger requalification costs, customer resistance, and compliance review friction.Pre-qualify multiple suppliers to the same critical specifications (identity, stereochemistry, impurities, stability and storage); document comparability and change-control pathways.
Sustainability
- Energy and emissions exposure from temperature-controlled storage/transport when refrigerated conditions (e.g., 2–8°C) are specified for certain commercial grades
Labor & Social
- Quality-system compliance and auditability (e.g., GMP expectations and traceable documentation) are central to responsible sourcing in supplement ingredient supply chains
FAQ
What is calcium L-methylfolate used for in supplements?It is used as a form of folate (vitamin B9) in dietary supplements, providing the 5-MTHF form of folate rather than folic acid. NIH’s Office of Dietary Supplements notes that some dietary supplements contain folate as 5-MTHF, and EFSA has evaluated calcium L-methylfolate as a 5-MTHF nutrient source in EU nutrition contexts.
How does EFSA treat calcium L-methylfolate in dietary folate equivalents (DFE)?EFSA’s 2022 opinion proposes DFE conversion equations for 5-MTHF sources including calcium L-methylfolate, applying a factor of 1.7 for intakes below 400 µg/day and a factor of 2.0 for food supplements providing 400 µg/day or more.
Why do some products use other 5-MTHF salts instead of the calcium salt?Some suppliers market alternative 5-MTHF salts (for example, a glucosamine salt) with different formulation characteristics. Gnosis by Lesaffre positions its glucosamine salt 5-MTHF ingredient as more water-soluble compared with the calcium salt, which it describes as sparingly soluble, which can matter for certain dosage forms and beverage-type applications.
Sources
Calcium L-methylfolate Country Coverage for Suppliers, Export Flows, and Prices
Explore country-level Calcium L-methylfolate market pages for supplier coverage, trade flows, and price benchmarks.
United Arab Emirates
Bolivia
Switzerland
China
Colombia
Ecuador
Spain
France
India
Italy
South Korea
Kazakhstan
All country market pages: United Arab Emirates, Bolivia, Switzerland, China, Colombia, Ecuador, Spain, France, India, Italy, South Korea, Kazakhstan, Sri Lanka, Mexico, Philippines, Pakistan, Russia, Turkiye, United States, Uzbekistan
Related Calcium L-methylfolate Product Categories
Browse parent, sub, derived, and raw-material product market pages related to Calcium L-methylfolate.
Parent product: Vitamin B9 (Folic Acid)
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