A recent USDA confirmation of highly pathogenic avian influenza (HPAI) in domestic livestock, including goats and dairy cattle, has raised concerns about the virus's adaptation and risks to swine. A collaborative webinar by the Swine Health Information Center and the American Association of Swine Veterinarians aimed to address these concerns. HPAI poses unique risks due to its segmented genome, which can lead to the exchange of gene segments, potentially making it more virulent. The ongoing research seeks to understand the virus's behavior in swine and assess the risks to both swine and human health. Preliminary findings suggest that swine can transmit HPAI, with some strains showing adaptation to mammals, although more research is needed. The article emphasizes the importance of awareness and vigilance among farmers to prevent further spread, particularly in environments where pigs and poultry coexist.