Over 16,000 sheep and goats have been culled in eastern Macedonia and Thrace due to smallpox, with the latest case reported in Karya of Nestos municipality. The region has imposed a ban on the movement of sheep and goats and closed slaughterhouses, with the outbreak affecting numerous farms across the area. Health officials are working to contain the disease and have urged breeders to cooperate to prevent further spread. The smallpox outbreak is posing significant challenges and requires extensive efforts to limit its spread both locally and internationally.