The article highlights the significant challenges faced by the Irish potato industry due to the emergence of the EU43 variant of the blight fungus, Phytophthora infestans, which is resistant to the carboxylic acid amide (CAA) group of fungicides. This variant, previously identified in Denmark and the Netherlands, poses a considerable threat due to its rapid life cycle and high mutation potential, necessitating more complex and costly blight prevention strategies. Experts from Teagasc, Kessel, and ADAS stress the importance of using a combination of fungicide molecules, developing blight-resistant potato varieties, and adopting effective crop management strategies to combat this and other resistant blight genotypes like EU46. The evolving nature of blight resistance, exacerbated by challenging weather conditions and the potential increase in management costs, underscores the urgent need for a multi-faceted response to protect the potato industry.