Australia is on high alert due to the spread of lumpy skin disease in cattle and buffalo across South-East Asia, which could potentially impact the country's economy through restrictions on cattle, meat, and dairy exports. The Australian government has secured a supply of vaccines, increased surveillance, and is developing a predictive model to assess the likely spread of the disease. The vaccines will also be available to Papua New Guinea and Timor-Leste. Maintaining a high level of preparedness and awareness among cattle producers, farmers, and veterinarians is crucial to maintain Australia's disease-free status as an international exporter.