Mexico and Cuba are working on a protocol to harmonize animal health requirements aiming to minimize the risks of introducing pests and diseases through the exchange of wild animals and livestock species. Both countries have a history of technical-scientific collaboration in human, animal, and plant health, and are focused on developing risk analysis to ensure safe commercial exchanges. The collaboration includes sharing techniques for eradicating plant pests and animal diseases, and a specific protocol for the identification of risk mitigation measures for the exchange of live animals.