The United States is not prepared for vaccinations against High Pathogenicity Avian Influenza (HPAI) due to the lack of a vaccine that matches the virus. The country is relying on biosecurity measures to contain the virus, which has been detected in wild aquatic birds, commercial poultry, and backyard flocks since January 2022. The virus has spread to 47 states, leading to the destruction of 58,645,211 birds. The virus has also been detected in Chile, marking the second human case of H5N1 in South America. The source of infection for the Chilean patient is under investigation.