The global banana industry is facing a crisis as the Panama disease, specifically the Tropical Race 4 (TR4) fungus, which has mutated and affects the currently grown Cavendish variety, is spreading rapidly. This fungus enters the plant through the roots, causing fusarium wilt, and has been detected in various banana-growing regions, including Australia and Peru. In response, the European Union-funded MUSA research project is exploring the use of natural agents in plant defense by studying microorganisms in the soil around plant roots. The project has identified microorganisms that can help activate the plant's natural defenses and attack pathogens. Additionally, the INDICANTS project aims to develop rapid tests to detect harmful pathogens in banana plants, and the MUSA team is working on commercial biocontrol products and innovations to reach farmers.