Dairy farmers in the Eastern Cape, South Africa, are requesting their animals be vaccinated against foot-and-mouth disease (FMD) to prevent its spread. Currently, vaccinated farms are considered FMD-positive, limiting the movement of cloven hooves and milk from these farms. The state veterinarian is processing applications for vaccination of FMD-free herds as quickly as possible. Milk SA is emphasizing the importance of biosecurity and caution, highlighting that vaccinated farms can still become infected and that vaccine immunity lasts only four to six months.