An outbreak of Salmonella in horses in Italy affected 17 people between June and November 2021, with the bacteria being detected three times in 152 horse cecal contents but not in carcass samples. The outbreak was linked to consumption of ground horse meat and smoked strips in Northern Italy, with whole genome sequencing matching the Salmonella strain found in the horses to an outbreak of 17 human cases. Environmental contamination in the slaughterhouse was identified as a likely source of the outbreak, prompting demands for improved hygiene measures and biosecurity protocols.