Researchers from the University of Udine and the Institute of Applied Genetics in Italy have discovered that grapes, now widespread in Europe, were first domesticated in the South Caucasus about 4000 years ago. This finding was based on a genetic analysis of a large number of grape varieties throughout Europe and the South Caucasus. The researchers suggest that the crossbreeding of South Caucasus grapes with European grapes helped the grapes survive colder winters in Europe and led to the diversity of the crop. An enzyme in wild grapes that was absent in European varieties was also identified, stimulating the production of growth hormone and increasing the size of the berries, making it suitable for both winemaking and human consumption.