Mexico's National Service of Agrifood Health, Safety and Quality (Senasica) is taking preventive measures to safeguard the national swine industry from the first outbreak of African swine fever (ASF) in the Dominican Republic. This includes reinforcing sanitary defense barriers, enhancing epidemiological surveillance, and strengthening laboratories and teams to combat the disease. Senasica is also encouraging pork producers to raise awareness and report any symptoms in pigs to the agency. The article provides a detailed overview of the symptoms, transmission, and countries affected by ASF, with a focus on the recent outbreaks in Asia and Europe. The Dominican Republic's case marks the first in the American continent, prompting heightened vigilance and action from Senasica and other North American health authorities.