A commercial broiler breeder flock in Mississippi has been infected with the highly pathogenic avian influenza (HPAI) H7N9 strain, marking the first detection of this strain in the United States since August 2017. An additional H5N9 strain was also identified for the first time in the country. The outbreak has led to the euthanization of over 47,600 chickens. The H7N9 strain has been responsible for severe respiratory problems in human cases, with the CDC reporting 1,668 infections and 616 deaths from 2013 to 2021. The United States is already grappling with the presence of the H5N1 strain in animals, with concerns of a potential future pandemic, especially after the first human death related to the H5N1 virus in early January.