The U.S. Department of Agriculture and NOAA Fisheries have launched the Northeast Oyster Breeding Centre, marking a significant advancement in shellfish farming. Located at the NOAA Fisheries Milford Laboratory, the centre aims to develop disease-resistant and climate change resilient Eastern oyster lines through advanced selective breeding. The first generation of oysters has been spawned and is being grown, with plans to evaluate their growth and performance. The lab is equipped with a flow-system and high-capacity hatchery, making it the first of its kind in North America. The collaboration between the agencies and the East Coast Shellfish Growers Association represents a major step forward for sustainable seafood and aquaculture innovation.