The article highlights the impact of the COVID-19 pandemic on the political economy of Africa, with a focus on Ghana's food systems. Conducted in partnership with NETRIGHT, a research study reveals the far-reaching effects of the pandemic on various aspects of the food value chain, including the transportation of commodities, trade, and food systems. The lockdown and border closures led to a disruption in the supply of essential food items like onions and tomatoes, imported from Niger and Burkina Faso respectively. This disruption resulted in significant challenges for farmers and traders, such as reduced sales, increased debt, and significant financial losses. The research underscores the need for government and stakeholder support to help traders and food system actors manage the financial debts incurred during the pandemic. It also emphasizes the importance of adopting proactive measures to improve food preservation and stabilize market prices to mitigate the negative effects on food systems.