Researchers in China have developed genetically modified dairy goats with increased resistance to mastitis using a gene editing strategy. The study, published in Advance Science, details how the researchers used the ISDra2-TnpB system to develop mastitis-resistant goats, which show increased levels of lysozyme in their mammary glands during E. coli infection. This reduction in severity of mastitis improves disease resistance in the goats. The research marks a significant step forward in breeding disease-resistant animals.