The article highlights the challenges of post-harvest losses in the fisheries sector of Lake Tanganyika, which can reach up to 70% during rainy seasons due to poor fishing, processing, and handling methods. These losses reduce the potential income of artisanal fishers, processors, and traders, who employ 27,000 fishermen and 11,000 processors in Tanzania, the leading producer of sardines, sprat, and perch in the lake. The FISH4ACP project, funded by the European Union and the German Federal Ministry, aims to improve and safeguard these value chains through various interventions, including improving fishing and processing methods, supporting cash-generating activities, rehabilitating and constructing landing sites, and promoting cooperative societies for artisanal fishermen. The project also involves all stakeholders in the value chain in research and outreach efforts to reduce post-harvest losses and enhance food security.