The re-election of President Donald Trump presents both opportunities and challenges for Vietnam's seafood exports to the US. Despite strict protection policies, Vietnam has managed to maintain its position as the US's largest seafood export market, with improving quality of Vietnamese seafood helping to mitigate the impact of political fluctuations. With the US-China trade conflict potentially leading to changes in the US supply chain, there is potential for Vietnam to increase its seafood exports to the US market. However, Vietnamese seafood enterprises face US trade defense measures and strict food safety standards, which could increase production and inspection costs and heighten competition with other seafood exporting countries. To capitalize on these opportunities, Vietnamese seafood enterprises must maintain high product quality, increase deep processing, exploit free trade agreements, and comply with US food safety regulations and sustainable production standards.