A collaborative research effort by scientists from the USDA’s Agricultural Research Service, Texas Tech University, Kansas State University, and West Texas A&M University has developed a reliable liver abscess model in cattle, demonstrating a 50% prevalence rate. This model, which is more consistent with a high-grain diet, aims to understand the development and triggers of liver abscesses, a condition causing significant economic losses up to $400 million annually. By inducing liver abscesses through an acidotic, high-grain diet and direct bacterial inoculation into the rumen, the study highlights the impact of diet on livestock health and the potential for developing non-antibiotic interventions. This research is crucial for the cattle industry, focusing on improving cattle well-being and reducing economic losses by gaining insights into the disease's etiology and physiological changes in affected cattle.