The Biological Institute (IB-APTA) of the Secretariat of Agriculture and Supply of São Paulo state has developed technologies that are used by all 120 national companies that produce biological inputs, resulting in an annual economic benefit of R$ 398.5 million. These technologies, which use specific strains for various crops, help control pests naturally and have led to significant cost savings in the use of traditional chemical products. The Institute maintains the Biological Control Innovation and Transfer Program (Probio) to promote innovation and technology transfer in biological control, and also works with companies in Paraguay and Panama.