The World Organisation for Animal Health (WOAH) has called for global vigilance against the spread of high pathogenicity avian influenza (HPAI) in animals, including mammals, due to its increasing incidence among dairy cattle in the United States. The virus, currently affecting over 30 mammal species, poses a threat to wildlife, domestic animals, and public health. The H5N1 strain detected in cattle raises concerns about its adaptation to mammals and possible transmission to other livestock and humans. Raw milk from infected cows has been identified as a high-risk factor for transmission. WOAH is closely monitoring the situation and emphasizes the importance of timely and transparent reporting to prevent misinformation. Currently, the risk to the public is low, but higher for those exposed to infected birds or environments. WOAH does not recommend trade restrictions on healthy cattle and their products unless justified by a risk analysis, in accordance with the WOAH Terrestrial Animal Health Code.