The U.S. turkey industry, a crucial part of the agricultural economy, produces over 216 million turkeys annually and contributes $103.4 billion. Key states include Minnesota, North Carolina, and Arkansas. The industry faces challenges from diseases like Highly Pathogenic Avian Influenza (HPAI), Avian Metapneumovirus (aMPV), and Turkey REO virus, which cause high mortality and economic losses. HPAI has significantly impacted turkeys since 2022, while aMPV and REO virus continue to pose threats. Effective biosecurity, vaccination, and surveillance are essential for disease management. The REO virus, affecting 2% of turkeys and 5% of toms in 2019, increases production costs due to higher mortality and reduced feed efficiency. Prevention and control strategies include biosecurity, flock management, and vaccination research, with the NTF Foundation funding efforts to develop better diagnostic tools and vaccines.