The article highlights the significance of bananas in Africa, particularly in the Great Lakes region, where it is a primary source of food and income for smallholder farmers. However, the production of bananas is threatened by various diseases and pests, with banana Xanthomonas wilt (BXW) being one of the most detrimental. Currently, there is no natural resistance to this disease, and conventional breeding methods are challenging due to the sterility and polyploid nature of most cultivars. Therefore, research has focused on developing transgenic bananas expressing genes that provide resistance to BXW, with initial trials showing promise in enhancing the trait durability of the transgenic events. These findings suggest a potential solution to improve banana production and food security in the region.