A study led by New York University has revealed evolutionary differences in corn, sorghum, and millet at the individual cell level, potentially paving the way for identifying genes that control important agricultural traits like drought tolerance. The research, published in Nature, shows that these crops have distinct adaptations, with sorghum being more drought-resistant than corn, and millet being a more distant relative. The team conducted single-cell mRNA profiling of the roots, identifying trends indicating cellular tinkering and gene module swapping between cell types over evolution. Future research will focus on how these single cells of the three crops respond to stress, such as drought, to identify the genes crucial for drought tolerance.