The Department of Animal Husbandry and Dairying (DAHD) in India has initiated a project called the One-Health Framework, in collaboration with the Bill & Melinda Gates Foundation and The Confederation of Indian Industry, to address issues at the intersection of animal, human, and environmental health. The project will be piloted in Karnataka and Uttarakhand, with the findings to be used to create a national One Health roadmap. This roadmap will help prevent future zoonotic disease outbreaks by providing better response mechanisms and incorporating global best practices. The project will also include a capacity-building plan for Karnataka and the launch of a One Health brochure in Kannada.