The African Swine Fever (ASF), a disease that has been severe in Africa, Europe, and Asia, with up to 100% mortality in pigs and no vaccine or cure, has been confirmed in pigs from the Dominican Republic, posing a threat to North America. This marks the first finding of ASF in the Western Hemisphere in nearly 40 years, prompting the World Organization for Animal Health (OIE) to call for immediate actions to contain its spread in the Americas. The United States and Canada are strengthening their surveillance and hosting an ASF Action Week to educate swine producers on the disease and prevention measures. The OIE emphasizes the importance of coordinated efforts to protect food security and livelihoods.