Pharmaceutical Grade Papain Suppliers & Prices in United States — Market Overview 2026
Parent Product
Papain
Last Updated
2026-09-01
Key takeaways for search and sourcing teams
- 2 sampled export transactions for United States are summarized.
- Page data last updated on 2026-09-01.
Pharmaceutical Grade Papain Export Supplier Intelligence, Price Trends, and Trade Flows in United States
2 export partner companies are tracked for Pharmaceutical Grade Papain in United States. Use Supply Chain Intelligence company profiles and analytics to validate exporter coverage, partner quality, and route priorities.
Explore Pharmaceutical Grade Papain export intelligence in United States, including 2 sampled supplier transactions, monthly unit-price ranges, and partner-country trade flow patterns for HS Code -.
Scatter points are sampled from 100.0% of the full transaction dataset.
Sample Export Supplier Transaction Records for Pharmaceutical Grade Papain in United States
2 sampled Pharmaceutical Grade Papain transactions in United States include date, origin, and partner-country context to benchmark export prices and supplier trading patterns.
Pharmaceutical Grade Papain sampled transaction unit prices by date in United States: 2025-10-31: 27.11 USD / kg, 2025-10-24: 26.83 USD / kg.
| Date | Reported Product | Unit Price | Exporter | Importer | |
|---|---|---|---|---|---|
| 2025-10-31 | SUP******** ************* ********** ****** ** ****** ** ** ** ******** **** ********* ***** ***** ********* | 27.11 USD / kg | (United States) | (Costa Rica) | |
| 2025-10-24 | SUP******** ************* ********** ****** ** ****** ** ** ** ******** **** ********* ***** ***** ********* | 26.83 USD / kg | (United States) | (Costa Rica) |
Top Pharmaceutical Grade Papain Export Suppliers and Companies in United States
Review leading exporter profiles and benchmark them against 2 total export partner companies tracked for Pharmaceutical Grade Papain in United States. Use Supply Chain Intelligence company profiles and analytics to shortlist sourcing and export partners faster.
(United States)
Latest Export Transaction: 2026-08-01
Employee Size: 101 - 500 Employees
Sales Revenue: USD 50M - 100M
Industries: Food ManufacturingFood PackagingFood WholesalersOthers
Value Chain Roles: Distribution / Wholesale
(United States)
Latest Export Transaction: 2026-08-01
Employee Size: Over 1000 Employees
Industries: Beverage ManufacturingFood ManufacturingOthers
Value Chain Roles: Food ManufacturingOthers
United States Export Partner Coverage
2 companies
Total export partner company count is a core signal of United States export network depth for Pharmaceutical Grade Papain.
Exporters and importers can open Supply Chain Intelligence company profiles and analytics to assess Pharmaceutical Grade Papain partner concentration, capacity signals, and trade relevance in United States.
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Classification
Product TypeIngredient
Product FormPowder (dry enzyme preparation)
Industry PositionFunctional enzyme ingredient (food processing aid and pharmaceutical-quality ingredient)
Market
Pharmaceutical-grade papain in the United States is primarily a regulated, downstream formulation and quality-driven market rather than a primary production origin. For food uses, papain is affirmed as a GRAS direct human food ingredient when used under current good manufacturing practice and meeting incorporated Food Chemicals Codex specifications. For pharmaceutical-quality use, buyers commonly reference USP–NF monograph expectations, including minimum enzyme activity specifications. Market access is therefore shaped more by documentation, conformance testing, and importer verification systems than by domestic agricultural seasonality.
Market RoleImport-dependent consumer and formulation market
Domestic RoleDownstream quality control testing, blending/standardization, repackaging, and distribution into food, dietary supplement, and pharmaceutical manufacturing channels
Market GrowthNot Mentioned
Specification
Physical Attributes
- Permitted for food use as an enzyme preparation in either liquid or dry form (food-grade context)
- Pharmaceutical-quality trade is commonly handled as a dry powder to support dosing and stability control (buyer practice varies)
Compositional Metrics
- USP–NF monograph specifies papain contains not less than (NLT) 6000 Units/mg (enzyme activity standard)
- Food-grade papain is required by regulation to meet incorporated Food Chemicals Codex specifications when used as a direct human food ingredient
Grades
- Food-grade: FCC-aligned specifications referenced in 21 CFR 184.1585
- Pharmaceutical-grade: USP–NF monograph conformance commonly required by regulated buyers
Packaging
- Moisture-barrier, sealed packaging with lot identification and Certificate of Analysis (CoA)
- Storage and handling controls focused on preventing moisture uptake and activity loss
Supply Chain
Value Chain
- Latex collection from unripe papaya (origin countries) -> aqueous extraction/filtration or precipitation -> drying -> activity standardization (may include dilution to official standard) -> bulk packaging -> import -> U.S. receiving QC and documentation review -> distribution to food/dietary supplement/pharmaceutical manufacturers
Temperature
- Maintain cool, dry storage conditions to protect enzyme activity and prevent caking/moisture-driven degradation
Atmosphere Control
- Moisture control (sealed containers, humidity management) is typically more critical than oxygen control for preserving activity
Shelf Life
- Shelf-life is sensitive to exposure to humidity and elevated temperatures; delays can trigger re-testing and potential lot rejection in regulated channels
Freight IntensityLow
Transport ModeMultimodal
Risks
Regulatory Compliance HighPharmaceutical-grade and regulated-channel buyers in the United States commonly require documented conformance to compendial/specification frameworks (e.g., USP–NF activity requirements) and robust quality documentation; nonconformance or documentation gaps can result in batch rejection, loss of approved-supplier status, and disruption of downstream manufacturing supply commitments.Implement a documented release program with CoA-to-spec verification (activity and identity), change-control notifications, and supplier qualification/audits aligned to the intended use (food vs pharmaceutical).
Regulatory Compliance MediumFood/ingredient shipments offered for import into the United States can be refused or delayed if Prior Notice is not submitted accurately and on time, creating delivery disruption and added storage/handling risk.Build a shipment-level compliance checklist to ensure Prior Notice data completeness, align broker/filing workflows, and keep contingency plans for holds and re-routing.
Worker Safety MediumPapain has been reported in the medical literature to cause occupational asthma and severe allergic reactions in exposed workers, which can trigger workplace health incidents and compliance issues for handlers of papain powder.Use closed handling where feasible, apply local exhaust ventilation and dust control, and enforce PPE and training for powdered enzyme handling.
Climate MediumUpstream papaya crop disease dynamics (notably papaya ringspot virus) can be highly disruptive to papaya production regions, creating supply tightness and price volatility for latex-derived enzyme inputs used to make papain.Diversify sourcing across origin countries/suppliers, maintain safety stocks for critical formulations, and monitor key origin-region crop disease alerts relevant to papaya.
Sustainability
- Upstream agricultural supply risk from papaya crop disease pressure in origin countries (e.g., papaya ringspot virus), which can tighten crude latex availability and raise sourcing volatility
Labor & Social
- Worker health risk: papain dust exposure has been associated in the literature with occupational sensitization, asthma, and severe allergic reactions; handling controls are important in warehouses and manufacturing environments
FAQ
Is papain permitted for use in food in the United States?Yes. FDA’s regulation at 21 CFR § 184.1585 affirms papain as generally recognized as safe (GRAS) for direct use in food when it meets the incorporated Food Chemicals Codex specifications and is used under current good manufacturing practice as an enzyme/processing aid/texturizer.
What activity specification is referenced for USP–NF papain used in pharmaceutical-quality contexts?The USP–NF monograph definition states that papain contains not less than (NLT) 6000 Units per milligram, and it describes the standardization concept for meeting the official activity standard.
What is a critical U.S. import compliance step for food-ingredient shipments of papain?FDA requires Prior Notice for food (including food ingredients) that is imported or offered for import into the United States, and inadequate Prior Notice can lead to refusal and holds at the port of entry.
Sources
Other Pharmaceutical Grade Papain Country Markets for Supplier, Export, and Price Comparison from United States
Compare Pharmaceutical Grade Papain supplier coverage, trade flows, and price benchmarks across countries related to United States.
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Related Pharmaceutical Grade Papain Product Categories
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Parent product: Papain
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