The first genetically modified lamb in Spain by the CSIC

Published Aug 12, 2024

Tridge summary

A team of researchers from CSIC has successfully created 'Teodoro,' Spain's first genetically modified lamb, featuring a mutation in a gene potentially linked to fertilization. This achievement aims to aid the study of reproductive failures in farm animals and provide insights into human fertilization. Researcher Pablo Bermejo-Álvarez highlighted the significance of genetically modified animal models in advancing biological knowledge, especially in reproduction. The team used Crispr technology to generate these modifications in bovine and ovine embryos produced entirely in vitro, a complex process previously limited to mice. The mutation was achieved through microinjection techniques combined with Crispr-Cas9 technology, similar to methods used for genetically edited rabbits in Spain.

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Original content

A group of CSIC researchers has obtained "Teodoro", the first genetically modified lamb in Spain, which was born with a mutation in a gene potentially involved in fertilization. This lamb will allow the study of reproductive failures in farm animals and be a model to understand fertilization in the human species, according to the center this Monday in a statement. Researcher Pablo Bermejo-Álvarez has pointed out that genetically modified animal models are "essential" to advance in the knowledge of any biological process, "including those involved in reproduction." Until the emergence of Crispr technology, the generation of these directed genetic modifications was carried out mainly in mice, since in other mammals it required "very complex and inefficient" techniques. Now, the INIA-CSIC research group is applying Crispr technology to generate this type of modification in bovine and ovine embryos produced completely "in vitro" to study the function of genes involved in different ...

Source: PEefeagro