The EU re-evaluation preliminary conclusion on propiconazole: Two new impurity controls added, continued registration pending.

Key changes: Active substance specification update This review updated the reference specifications for propiconazole, adding two related impurities with the following specific requirements: Toxicology and consumer risk No critical toxicological issues were found with propiconazole itself, and the consumer exposure to its metabolite M04 (desulfuryl propiconazole) is below 15% of the toxicological reference values (TRVs), making the risk manageable. The main uncertainty lies in the metabolites: due to insufficient data to rule out the potential genotoxicity of metabolites M15, M17, M33, and M35, the overall consumer dietary risk assessment is considered a provisional conclusion, pending resolution of the aforementioned concerns. For triazole-derived metabolites (TDM) assessment, the exposure from propiconazole is lower than the results of the previous TDM special assessment. Efficacy evaluation Propiconazole, as a fungicide, has sufficient control effects on target diseases in the ...