Core Tip: On July 25, 2025— the European Food Safety Authority (EFSA) recently initiated a safety evaluation of β-nicotinamide mononucleotide (NMN) as a novel food, with the public consultation document numbered PC-1537, the applicant being Shanghai Shangke Biotechnology from China. This move marks the formal entry of the highly anticipated anti-aging ingredient NMN into the European Union's regulatory review process. If approved, it will become the first NMN ingredient legally used across the European Union, triggering the global anti-aging market.