Researchers from KAUST and collaborators have assembled the highest quality genome to date for bread wheat, focusing on a South African wheat cultivar called Kariega, which has robust resistance to stripe rust. They identified and cloned a key gene, Yr27, that confers stripe rust resistance, which could be transferred to other cultivars during breeding. The team's strategy could be used to clone all 400 disease resistance genes found in wheat, potentially eradicating major wheat diseases.