Highly pathogenic avian flu outbreaks are impacting poultry farms in the United States and abroad, leading to concerns about the impact on the industry. This has resulted in discussions about the potential use of poultry vaccination to mitigate the impact, with the World Organization for Animal Health stating that vaccination, when conducted properly and based on science, should not be a barrier to trade. Outbreaks in 6 states in the US and further H5N1 events overseas, including detections in polar bears and squirrels, have highlighted the need for a review of prevention and control strategies to address the evolving virus.