Parent Product
Enzymes
Sub Product
Bromelain, Papain
Last Updated
2026-05-10
Key takeaways for search and sourcing teams
- Proteases market coverage spans 62 countries.
- 540 exporter companies and 710 importer companies are indexed in the global supply chain intelligence network for this product.
- 1,970 supplier-linked transactions are summarized across the top 20 countries.
- 1 premium suppliers and 0 catalog items are currently listed.
- Wholesale sample entries: 0; farmgate sample entries: 0.
- Page data last updated on 2026-05-10.
Global Supplier Transactions, Export Activity, and Price Benchmarks for Proteases
Analyze 1,970 supplier-linked transactions across the top 20 countries, with monthly unit-price benchmarks to track export competitiveness and sourcing risk for Proteases.
Proteases Country YoY Change in Supplier Transactions and Export Momentum
Compare positive and negative YoY shifts in Proteases to identify accelerating supplier markets and weakening export corridors.
Top YoY shifts for Proteases: Germany (+309.5%), United States (+137.4%), Brazil (+113.5%).
Proteases Country-Level Supplier Transaction and Unit Price Summary
As of 2025-06, benchmark Proteases country transaction counts with monthly unit price and volume to prioritize supplier and export markets.
In 2025-11, countries with visible Proteases transaction unit prices: Germany (84.58 USD / kg), United States (70.11 USD / kg), Ireland (67.21 USD / kg), Belgium (63.93 USD / kg), Japan (62.27 USD / kg), 11 more countries.
| Country | YoY Change | Transaction Count | 2025-06 | 2025-07 | 2025-08 | 2025-09 | 2025-10 | 2025-11 | 2025-12 | 2026-01 | 2026-02 | 2026-03 | 2026-04 | 2026-05 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Denmark | +14.7% | 229 | 11.67 USD / kg (118,265.2 kg) | 10.97 USD / kg (183,280.8 kg) | 7.94 USD / kg (218,196.7 kg) | 26.35 USD / kg (203,027.35 kg) | 50.59 USD / kg (15,261.48 kg) | 13.19 USD / kg (155,161 kg) | ||||||
| India | +6.5% | 418 | 18.22 USD / kg (53,781.52 kg) | 17.18 USD / kg (123,965.8 kg) | 26.54 USD / kg (71,025.005 kg) | 20.49 USD / kg (66,254.765 kg) | 24.89 USD / kg (14,541 kg) | 15.75 USD / kg (11,452.5 kg) | ||||||
| China | -19.4% | 315 | 9.88 USD / kg (8,680.98 kg) | 16.79 USD / kg (129,382.89 kg) | 6.15 USD / kg (115,692.51 kg) | 12.35 USD / kg (122,987.32 kg) | 22.67 USD / kg (133,412.7 kg) | 5.37 USD / kg (73,404.8 kg) | ||||||
| Netherlands | -3.4% | 96 | 16.62 USD / kg (23,107.21 kg) | 18.80 USD / kg (76,463.7 kg) | 19.62 USD / kg (49,070 kg) | 21.87 USD / kg (30,918.07 kg) | 9.28 USD / kg (49,724.75 kg) | 12.00 USD / kg (43,718.33 kg) | ||||||
| Malaysia | +0.4% | 40 | 37.12 USD / kg (1,200 kg) | 37.12 USD / kg (2,475 kg) | 20.14 USD / kg (32,950 kg) | 29.34 USD / kg (1,200 kg) | 37.12 USD / kg (1,200 kg) | 37.12 USD / kg (600 kg) | ||||||
| Japan | +13.4% | 33 | - (-) | 121.25 USD / kg (40 kg) | 174.17 USD / kg (1,162.22 kg) | 41.51 USD / kg (105.46 kg) | 82.15 USD / kg (68.7 kg) | 62.27 USD / kg (26,046 kg) | ||||||
| Ireland | -4.7% | 17 | 19.99 USD / kg (20 kg) | 38.20 USD / kg (684 kg) | 84.26 USD / kg (616.48 kg) | 5.90 USD / kg (-) | - (-) | 67.21 USD / kg (0.28 kg) | ||||||
| Mexico | -12.1% | 198 | 35.03 USD / kg (2,505 kg) | 29.83 USD / kg (20,695.27 kg) | 19.64 USD / kg (36,064 kg) | 20.85 USD / kg (20,600 kg) | 25.22 USD / kg (16,936.5 kg) | 21.92 USD / kg (32,541.6 kg) | ||||||
| United States | +137.4% | 175 | 4.92 USD / kg (71,118.699 kg) | 6.74 USD / kg (108,869.27 kg) | 34.14 USD / kg (454.99 kg) | 12.25 USD / kg (133,784.67 kg) | 15.64 USD / kg (38,509.284 kg) | 70.11 USD / kg (210.25 kg) | ||||||
| Brazil | +113.5% | 60 | 8.52 USD / kg (15,515 kg) | 8.74 USD / kg (3,174.75 kg) | 6.71 USD / kg (26,800 kg) | 9.89 USD / kg (54,374.48 kg) | 13.61 USD / kg (2,252.87 kg) | 12.43 USD / kg (7,141.72 kg) |
Proteases Global Supply Chain Coverage
1,250 companies
540 exporters and 710 importers are mapped for Proteases.
Exporters and importers can use Tridge Supply Chain Intelligence company profiles and analytics to identify counterparties for Proteases, benchmark reach, and prioritize outreach by market.
Proteases Export Supplier Intelligence, Trade Flows, and Price Signals
540 exporter companies are mapped in Tridge Supply Chain Intelligence for Proteases. Exporters and importers can use company profiles and analytics to evaluate supplier coverage, trading activity, and route opportunities.
Proteases Verified Export Suppliers and Premium Partners
1 premium Proteases suppliers include country, industry, and contactability signals to prioritize credible export partners faster.
SM Empreendimentos Farmacêuticos Ltda.
Brazil
Others
Become a Premium Supplier to join the Tridge Supply Chain Network and advance your marketing and export channel strategy.
Classification
Product TypeIngredient
Product FormPowder or Liquid (Food-Grade Enzyme Preparation)
Industry PositionFood Processing Aid / Ingredient
Market
Proteases are traded globally as food-grade enzyme preparations (often captured in HS 3507/350790 “prepared enzymes, n.e.s.”) and are used in food processing to hydrolyze proteins and polypeptides (e.g., protein hydrolysates, certain beverage applications, and other process uses). Trade in prepared enzymes is concentrated among a small set of exporting countries, with major import demand in large processing markets and distribution hubs. Market access is shaped by regulatory frameworks for food enzymes/additives, including Codex GSFA/JECFA specifications and jurisdiction-specific authorization pathways (e.g., FDA food additive/GRAS approaches and EFSA’s EU food enzyme evaluation process). Because enzyme preparations are active proteins used at low levels and often removed or inactivated during processing, buyers typically emphasize documented identity/purity specifications, activity, and compliance over commodity-style grading.
Major Producing Countries
- DenmarkMajor exporting country for HS 350790 prepared enzymes in 2023 (used here as a proxy indicator of industrial enzyme manufacturing scale).
- United StatesMajor exporting country for HS 350790 prepared enzymes in 2023 (proxy indicator).
- NetherlandsMajor exporting country for HS 350790 prepared enzymes in 2023; also a key European logistics and redistribution hub.
- GermanyMajor exporting country for HS 350790 prepared enzymes in 2023 (proxy indicator).
- ChinaSignificant exporting country for HS 350790 prepared enzymes in 2023 (proxy indicator).
- FranceSignificant exporting country for HS 350790 prepared enzymes in 2023 (proxy indicator).
Major Exporting Countries
- United StatesAmong the top exporting countries by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- DenmarkAmong the top exporting countries by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- NetherlandsAmong the top exporting countries by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- GermanyAmong the top exporting countries by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- ChinaAmong the top exporting countries by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- FranceAmong the top exporting countries by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
Major Importing Countries
- United StatesLargest single import market by value for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- NetherlandsMajor import market for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023); often functions as an EU distribution hub.
- GermanyMajor import market for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- ChinaMajor import market for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- FranceMajor import market for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
- BrazilSignificant import market for HS 350790 prepared enzymes (UN Comtrade via WITS, 2023).
Specification
Major VarietiesBromelain (pineapple-derived protease), Papain (papaya-derived protease), Trypsin (porcine or bovine pancreas-derived protease), Pancreatin (porcine or bovine pancreatic tissue; proteolytic activity), Pepsin (hog stomach-derived protease), Ficin (Ficus-derived peptide hydrolase), Microbial protease preparations (e.g., Bacillus-derived protease blends)
Physical Attributes
- Protein-based biocatalyst supplied as a formulated enzyme preparation (often powder or liquid), with declared activity for a defined technological effect.
- Enzyme preparations may contain intentionally added formulation ingredients such as diluents, stabilizers, or preservatives, and may contain constituents from the source and manufacturing process.
Compositional Metrics
- Declared enzyme activity (assay-based) is a core commercial specification parameter for protease preparations.
- Identity and purity specifications and testing expectations for enzyme preparations are commonly referenced in JECFA specifications (including general specifications for enzyme preparations used in food processing).
Grades
- Food-grade enzyme preparation aligned to applicable identity/purity specifications (e.g., JECFA enzyme-preparation specifications) and jurisdictional authorization/acceptance conditions.
ProcessingProteases (peptidases) hydrolyze peptide bonds; functionality is process-dependent (e.g., time/temperature/pH), and enzymes may be removed from the final food or inactivated by heat depending on the application.
Supply Chain
Value Chain
- Production strain cultivation or source extraction (microbial fermentation; plant/animal tissue extraction) -> recovery/filtration -> purification/concentration -> formulation/standardization (diluents/stabilizers as appropriate) -> quality testing to specification -> packaging -> distribution to industrial food processors
Demand Drivers
- Use of protease preparations in food processing to hydrolyze proteins and polypeptides (including production of protein hydrolysates and certain beverage-related uses).
- Process performance needs (yield, processing efficiency, product quality attributes) that can be enabled by enzyme-based processing steps under regulated conditions.
Temperature
- Many enzyme preparations used in food processing are applied at low levels and may be removed during downstream purification steps or inactivated by high temperatures during processing (application-dependent).
Risks
Regulatory Compliance HighProtease preparations can face market-access disruption because food-enzyme oversight differs by jurisdiction (e.g., authorization pathways and dossier requirements, and whether the use is treated as an additive or a processing aid). Non-alignment with required specifications, permitted-use conditions, or authorization status can lead to shipment holds, delisting, or reformulation pressure in destination markets.Maintain jurisdiction-specific regulatory dossiers and specifications; ensure alignment to recognized identity/purity expectations (e.g., JECFA enzyme-preparation specifications) and destination-market authorization/notification requirements (e.g., FDA and EFSA pathways as applicable).
Occupational Health MediumEnzyme proteins can act as respiratory sensitizers when airborne exposure occurs; published occupational studies in enzyme-using industries report sensitization and work-related symptoms associated with exposure peaks. This can disrupt operations via worker health impacts, compliance actions, and required process changes.Use low-dust formulations where feasible; implement engineering controls (enclosed transfer, local exhaust ventilation), exposure monitoring, and handling instructions to minimize dust/aerosols.
Food Safety MediumFood enzyme preparations can contain residuals linked to the source organism and manufacturing process (e.g., fermentation medium residues), making control of impurities and microbiological quality critical. Failure to meet identity/purity specifications or unintended contamination events can trigger recalls, customer rejections, and regulatory scrutiny.Qualify suppliers against recognized specifications for enzyme preparations; require lot-level COAs (activity, identity/purity tests) and robust QA/QC release criteria.
Supply Concentration MediumInternational trade data for prepared enzymes (HS 350790, which includes enzyme preparations such as proteases but is not protease-exclusive) indicates export value concentration among a limited number of countries. Disruptions in major exporting countries (capacity constraints, regulatory actions, or logistics shocks) can tighten supply for downstream users.Dual-source across regions; pre-qualify substitute enzyme preparations and maintain change-control plans for formulation/process transitions.
Labor & Social
- Occupational respiratory sensitization risk from airborne enzyme proteins (including proteases) in manufacturing, packing, and dosing/handling settings; risk management emphasizes controlling dust/aerosols and applying appropriate process controls.
FAQ
Which countries are major exporters of prepared enzyme products used as a proxy for protease preparations in trade data?Using UN Comtrade data accessed via the World Bank’s WITS tool for HS 350790 (prepared enzymes, n.e.s.) as a proxy category that can include protease preparations, major exporting countries in 2023 include the United States, Denmark, the Netherlands, Germany, China, and France.
How are protease enzyme preparations regulated for food use internationally?Regulatory treatment varies by jurisdiction, but global reference points include Codex GSFA and JECFA identity/purity specifications for enzyme preparations, while national/regional authorities apply their own authorization or notification pathways (for example, FDA’s food additive/GRAS frameworks in the United States and EFSA’s food enzyme application and evaluation process in the European Union).
What is a key worker-safety risk when handling protease enzyme products?Protease and other enzyme proteins can cause occupational respiratory sensitization if airborne exposure occurs, particularly when handling powders that generate dust; industry safety guidance emphasizes controlling dust/aerosols through process controls and appropriate handling practices.
Sources
Proteases Country Coverage for Suppliers, Export Flows, and Prices
Explore country-level Proteases market pages for supplier coverage, trade flows, and price benchmarks.
Andorra
United Arab Emirates
Argentina
Austria
Australia
Bangladesh
Belgium
Bulgaria
Bolivia
Brazil
Canada
Switzerland
All country market pages: Andorra, United Arab Emirates, Argentina, Austria, Australia, Bangladesh, Belgium, Bulgaria, Bolivia, Brazil, Canada, Switzerland, Chile, China, Colombia, Costa Rica, Germany, Denmark, Ecuador, Egypt, Spain, Finland, France, United Kingdom, Guatemala, Hong Kong, Indonesia, Ireland, India, Iran, Italy, Japan, South Korea, Kazakhstan, Sri Lanka, Lesotho, Mexico, Malaysia, Nigeria, Netherlands, Nepal, New Zealand, Panama, Peru, Philippines, Pakistan, Poland, Paraguay, Serbia, Russia, Singapore, El Salvador, Thailand, Turkiye, Taiwan, Ukraine, Uganda, United States, Uruguay, Uzbekistan, Vietnam, South Africa
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