The UK has confirmed the presence of the Seneca Valley virus on several farms, marking the first detection of this virus in Europe. The virus, which was discovered in 2002 and has been proposed for human tumor treatment, causes symptoms similar to foot-and-mouth disease in pigs. The clinical signs include lesions that evolve into vesicles and ulcers, and can lead to piglet mortality and diarrhea. The virus is most likely already in continental Europe, and there is concern for the potential for more cases to emerge. Any case of vesicular disease in pigs should be sampled and sent to a national reference laboratory to discover epidemiological factors associated with the virus.