Brazil is set to begin the second phase of foot-and-mouth disease vaccination for cattle and buffaloes under two years old in November, with the aim to immunize around 70 million animals across most states. The vaccination, along with the completion and submission of vaccination declarations, are crucial in maintaining the country's foot-and-mouth disease-free status. Authorized resellers will supply the vaccines, which must be stored between 2°C and 8°C until use. The Department of Animal Health has published two crucial documents: the Vesicular Disease Investigation Manual and the Contingency Plan for Foot-and-Mouth Disease. These guides, adhering to international standards, aim to ensure a prepared and efficient response in case of an outbreak, supporting the expansion of foot-and-mouth disease-free zones without vaccination as part of the national strategic plan.