The avian influenza A/H5N1 virus, specifically the 2.3.4.4b clade, has caused mass mortality in both domestic and wild birds since 2020, spreading to multiple continents and resulting in millions of deaths. The virus has also impacted mammalian species, with outbreaks reported in 10 countries on three continents. While the risk of human infection is currently low, global cooperation is needed to protect animal and human health and prevent further economic damage.