Australia and New Zealand are intensifying their biosecurity efforts to safeguard against the infiltration of the H5N1 bird flu virus subtype 2.3.4.4b, a strain that has wreaked destruction across Asia, Europe, and Africa since 2020. This strain has recently reached Indonesia and Antarctica, posing a significant threat to Oceania's ecosystems, including endangered species and its agricultural industry. Both countries are implementing measures such as enhancing farm biosecurity, testing and vaccinating vulnerable species, and developing response plans. Australia is also working on vaccination options for endangered wild birds in captivity. Farmers are adopting practices to limit wild bird-poultry contact, while New Zealand is learning from farms in Australia and Britain. The situation underscores the challenges of balancing wildlife conservation with safeguarding agricultural interests in the face of a global health crisis.