Mycoplasma bacteria, which can be spread by other bacteria or viruses, is linked to respiratory problems in cattle and can also cause mastitis, arthritis, and swollen legs in heifers. The recent spread of Mycoplasma bovis in the UK makes it important for farmers to include mycoplasma in serological testing to understand the potential risks and plan disease management accordingly. The bacteria's ability to change surface proteins and produce a sugar matrix biofilm makes it difficult to treat, particularly in dairy beef systems. A whole herd approach to health management, including vaccines and other factors, is recommended to minimize the risk of mycoplasma infection.