The United States has initiated formal trade negotiations with Mexico over Mexico's plans to restrict imports of genetically modified (GM) corn and other agricultural products. This is the initial step towards requesting a dispute settlement panel under the USMCA, which could result in US tariffs if no resolution is reached. The dispute threatens to disrupt the estimated $5 billion worth of US corn exports to Mexico and could impede biotech innovation, especially amidst high food inflation and increasing climate challenges. Both countries are hopeful for productive talks to address the issue.