The recent outbreak of avian influenza at a Cal-Maine Foods farm in Texas has highlighted the significant impact of the disease on North America, where over 100 million birds have been culled to control its spread, predominantly in the United States. This situation underscores the urgent need for enhanced biosecurity measures at poultry farms, better monitoring and control of bird and poultry product imports, and increased collaboration between the United States, Canada, and Mexico. These steps are crucial to protect the ecosystem, economy, and prevent further outbreaks of the highly pathogenic avian influenza (HPAI).